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Slc26a5tm1Jnz
Targeted Allele Detail
Nomenclature
Symbol: Slc26a5tm1Jnz
Name: solute carrier family 26, member 5; targeted mutation 1, Jian Zuo
MGI ID: MGI:2387795
Synonyms: prestin-KO
Gene: Slc26a5  Location: Chr5:21810655-21865604 bp, - strand  Genetic Position: Chr5, 9.97 cM, cytoband A3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:79029
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 3 through 7 were replaced by a neomycin selection cassette inserted by homologous recombination. The deleted region encoded 245 amino acids encompassing the start codon, a conserved STAT motif, positively charged residues involved in intracellular anion binding, and the first 5 of the the 12 transmembrane domains. Neither transcript nor protein was detected in homozygous mice by RT-PCR and Western blot analyses. (J:79029)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Slc26a5 Mutation:  34 strains or lines available
References
Original:  J:79029 Liberman MC, et al., Prestin is required for electromotility of the outer hair cell and for the cochlear amplifier. Nature. 2002 Sep 19;419(6904):300-4
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/30/2020
MGI 6.15
The Jackson Laboratory