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Serpine2tm1Dmn
Targeted Allele Detail
Nomenclature
Symbol: Serpine2tm1Dmn
Name: serine (or cysteine) peptidase inhibitor, clade E, member 2; targeted mutation 1, Denis Monard
MGI ID: MGI:2387774
Synonyms: PN-1-, SE2-
Gene: Serpine2  Location: Chr1:79794317-79858665 bp, - strand  Genetic Position: Chr1, 40.97 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:40953
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe gene was disrupted by insertion of a neomycin resistance cassette into exon 2 via homologous recombination. The targeted mutation removes 99 bp of exon 2 including the translation initiation codon. Absence of gene expression in homozygous mutant animals was confirmed by Nothern blot and Western blot analysis of brain samples. (J:40953)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Serpine2 Mutation:  1 strain or line available
References
Original:  J:40953 Luthi A, et al., Endogenous serine protease inhibitor modulates epileptic activity and hippocampal long-term potentiation. J Neurosci. 1997 Jun 15;17(12):4688-99
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/31/2020
MGI 6.15
The Jackson Laboratory