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Kif1btm1Noh
Targeted Allele Detail
Nomenclature
Symbol: Kif1btm1Noh
Name: kinesin family member 1B; targeted mutation 1, Nobutaka Hirokawa
MGI ID: MGI:2387573
Synonyms: kif1B-
Gene: Kif1b  Location: Chr4:149176319-149307693 bp, - strand  Genetic Position: Chr4, 79.05 cM, cytoband E
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:69772
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsSequence encoding the ATP binding consensus P loop of the motor domain was replaced with a neomycin cassette by homologous recombination. Western blot analysis of brain crude extracts showed both the alpha and beta isoforms to be absent in homozygous mice. (J:69772)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 10 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kif1b Mutation:  30 strains or lines available
References
Original:  J:69772 Zhao C, et al., Charcot-Marie-Tooth disease type 2A caused by mutation in a microtubule motor KIF1Bbeta. Cell. 2001 Jun 1;105(5):587-97
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory