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Tg(Defcr2-TAg)#Jig
Transgene Detail
Nomenclature
Symbol: Tg(Defcr2-TAg)#Jig
Name: transgene insertion #, Jeffrey I Gordon
MGI ID: MGI:2387572
Synonyms: CR2-TAg, CR2-T-Ag, Tg(CR2-TAg)#Jig
Transgene: Tg(Defcr2-TAg)#Jig  Location: unknown  
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsThis transgene contains the mouse Defcr2 (defensin related cryptdin 2) promoter region (-6500 to +34) and the wild-type allele of the SV40 large T antigen (Tag) gene. Expression of the transgene is targeted to neuro-endocrine cells of the prostate gland. The Defcr2 promoter was originally observed to drive expression in Paneth cells of intestinal crypts and subsequently in prostatic epithelium. Eight lines were established but the references do not distinguish between them. Data may have been pooled from more than one line. (J:43025, J:51704)
Phenotypes
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Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:43025 Garabedian EM, et al., Examining the role of Paneth cells in the small intestine by lineage ablation in transgenic mice. J Biol Chem. 1997 Sep 19;272(38):23729-40
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/19/2020
MGI 6.15
The Jackson Laboratory