Zeb2^tm1Yhi
Targeted Allele Detail

Summary

• Symbol: Zeb2^tm1Yhi
• Name: zinc finger E-box binding homeobox 2; targeted mutation 1, Yujiro Higashi
• MGI ID: MGI:2387493
• Synonyms: SIP1^{flox(neo,ex7)}
• Gene: Zeb2 Location: Chr2:44873644-45007407 bp, - strand Genetic Position: Chr2, 27.31 cM, cytoband C1
• Alliance: Zeb2^tm1Yhi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75138
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 7, which encodes the fourth zinc finger of the amino terminal zinc finger cluster, the Madh binding domain, the homeodomain like sequence, and the CtBP binding sites, was flanked by an upstream floxed neo cassette and a downstream single loxP site. (J:75138)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zeb2 Mutation: 76 strains or lines available

References

• Original: J:75138 Higashi Y, et al., Generation of the floxed allele of the SIP1 (Smad-interacting protein 1) gene for Cre-mediated conditional knockout in the mouse. Genesis. 2002 Feb;32(2):82-4
• All: 1 reference(s)