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Tnfrsf17tm1Msc
Targeted Allele Detail
Nomenclature
Symbol: Tnfrsf17tm1Msc
Name: tumor necrosis factor receptor superfamily, member 17; targeted mutation 1, Martin L Scott
MGI ID: MGI:2387427
Synonyms: BCMA-
Gene: Tnfrsf17  Location: Chr16:11313812-11320074 bp, + strand  Genetic Position: Chr16, 6.42 cM, cytoband B3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:71681
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA region of the gene containing the translation initiation codon and 1.3 kb of downstream sequences were replaced with a human CD2 reporter gene fused to a neomycin resistance cassette. The mutation deletes the first 87 residues, which includes a putative transmembrane domain. Northern blot analysis of spleen RNA using probes to the deleted region did not detect gene transcript in homozygous mutant animals. (J:71681)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tnfrsf17 Mutation:  18 strains or lines available
References
Original:  J:71681 Schiemann B, et al., An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway. Science. 2001 Sep 14;293(5537):2111-4
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/17/2019
MGI 6.14
The Jackson Laboratory