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Targeted Allele Detail
Symbol: Timp3tm1Rkho
Name: tissue inhibitor of metalloproteinase 3; targeted mutation 1, Rama Khokha
MGI ID: MGI:2387409
Synonyms: timp-3-, Timp-3-null
Gene: Timp3  Location: Chr10:86300372-86349506 bp, + strand  Genetic Position: Chr10, 42.83 cM, cytoband C1-D1
Germline Transmission:  Earliest citation of germline transmission: J:71609
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe gene was disrupted by replacement of part of exon 1 (just upstream of the translation initiation codon) to part of exon 2 (after the conserved VIRAK codons) with a neomycin resistance cassette in the reverse orientation. Northern blot of lung, kidney, and heart RNA and RT-PCR analysis did not detect gene expression in homozygous mutants. Reverse zymographic analysis of kidney extracts did not detect protein activity in homozygous animals. (J:71609)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 46 assay results
In Structures Affected by this Mutation: 15 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Timp3 Mutation:  9 strains or lines available
Original:  J:71609 Leco KJ, et al., Spontaneous air space enlargement in the lungs of mice lacking tissue inhibitor of metalloproteinases-3 (TIMP-3). J Clin Invest. 2001 Sep;108(6):817-29
All:  39 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
The Jackson Laboratory