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Targeted Allele Detail
Symbol: G6pctm1Jyc
Name: glucose-6-phosphatase, catalytic; targeted mutation 1, Janice Yang Chou
MGI ID: MGI:2387343
Synonyms: G6Pase-, Glc-6-Pase-alpha-
Gene: G6pc  Location: Chr11:101367561-101377903 bp, + strand  Genetic Position: Chr11, 64.83 cM
Germline Transmission:  Earliest citation of germline transmission: J:33212
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 3 was replaced with a neomycin selection cassette via homologous recombination. Neither transcript nor protein were detected in homozygous mutant mice by a protection assay and Western blot analysis of liver and kidney tissues. Functional ablation was confirmed by the absence of glucose-6-phosphate hydrolysis in liver and kidney microsomes obtained from homozygous mutant mice. (J:33212)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any G6pc Mutation:  2 strains or lines available
Original:  J:33212 Lei KJ, et al., Glucose-6-phosphatase dependent substrate transport in the glycogen storage disease type-1a mouse. Nat Genet. 1996 Jun;13(2):203-9
All:  12 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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