G6pc1tm1Jyc
Targeted Allele Detail
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Symbol: |
G6pc1tm1Jyc |
Name: |
glucose-6-phosphatase catalytic subunit 1; targeted mutation 1, Janice Yang Chou |
MGI ID: |
MGI:2387343 |
Synonyms: |
G6Pase-, Glc-6-Pase-alpha- |
Gene: |
G6pc1 Location: Chr11:101258542-101268729 bp, + strand Genetic Position: Chr11, 64.83 cM
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Alliance: |
G6pc1tm1Jyc page
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Germline Transmission: |
Earliest citation of germline transmission:
J:33212
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Parent Cell Line: |
J1 (ES Cell)
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Strain of Origin: |
129S4/SvJae
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Exon 3 was replaced with a neomycin selection cassette via homologous recombination. Neither transcript nor protein were detected in homozygous mutant mice by a protection assay and Western blot analysis of liver and kidney tissues. Functional ablation was confirmed by the absence of glucose-6-phosphate hydrolysis in liver and kidney microsomes obtained from homozygous mutant mice.
(J:33212)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any G6pc1 Mutation: |
18 strains or lines available
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Original: |
J:33212 Lei KJ, et al., Glucose-6-phosphatase dependent substrate transport in the glycogen storage disease type-1a mouse. Nat Genet. 1996 Jun;13(2):203-9 |
All: |
18 reference(s) |
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