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Erbb2tm1Klee
Targeted Allele Detail
Nomenclature
Symbol: Erbb2tm1Klee
Name: v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian); targeted mutation 1, Kuo-Fen Lee
MGI ID: MGI:2387154
Synonyms: erbB2 floxed
Gene: Erbb2  Location: Chr11:98412470-98437716 bp, + strand  Genetic Position: Chr11, 61.75 cM, cytoband D
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:76196
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA 3.0 kb region containing 1.5 kb of the endogenous promoter and exon 1 was flanked by loxP sites. Exon 1 encodes amino acids 1 through 27. (J:76196)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Erbb2 Mutation:  3 strains or lines available
Notes
Phenotypic Similarity to Human Syndrome: Hirschsprung Disease in mice homozygous for this allele and hemizygous for Tg(Nes-cre)1Atp (J:81239)

References
Original:  J:76196 Crone SA, et al., ErbB2 is essential in the prevention of dilated cardiomyopathy. Nat Med. 2002 May;8(5):459-65
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory