About   Help   FAQ
Targeted Allele Detail
Symbol: Erbb2tm1Klee
Name: v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian); targeted mutation 1, Kuo-Fen Lee
MGI ID: MGI:2387154
Synonyms: erbB2 floxed
Gene: Erbb2  Location: Chr11:98412470-98437716 bp, + strand  Genetic Position: Chr11, 61.75 cM, cytoband D
Germline Transmission:  Earliest citation of germline transmission: J:76196
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA 3.0 kb region containing 1.5 kb of the endogenous promoter and exon 1 was flanked by loxP sites. Exon 1 encodes amino acids 1 through 27. (J:76196)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Erbb2 Mutation:  3 strains or lines available
Phenotypic Similarity to Human Syndrome: Hirschsprung Disease in mice homozygous for this allele and hemizygous for Tg(Nes-cre)1Atp (J:81239)

Original:  J:76196 Crone SA, et al., ErbB2 is essential in the prevention of dilated cardiomyopathy. Nat Med. 2002 May;8(5):459-65
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.01
The Jackson Laboratory