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Targeted Allele Detail
Symbol: Skiltm1Sis
Name: SKI-like; targeted mutation 1, Shunsuke Ishii
MGI ID: MGI:2387096
Synonyms: sno-/-
Gene: Skil  Location: Chr3:31149207-31176726 bp, + strand  Genetic Position: Chr3, 15.12 cM
Alliance: Skiltm1Sis page
Germline Transmission:  Earliest citation of germline transmission: J:62174
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Allele Type:    Targeted (Null/knockout)
Mutation:    Disruption caused by insertion of vector
Mutation detailsThe exon encoding amino acids 1 through 362 and common to all known isoforms produced from the endogenous locus was replaced by a neomycin selection cassette inserted via homologous recombination. Western blot analyses using antibodies for both amino and carboxy terminals showed protein levels in heterozygous mutant mice to be approximately half of the wild-type levels. (J:62174)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Skil Mutation:  34 strains or lines available
Original:  J:62174 Shinagawa T, et al., The sno gene, which encodes a component of the histone deacetylase complex, acts as a tumor suppressor in mice. EMBO J. 2000 May 15;19(10):2280-91
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory