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Targeted Allele Detail
Symbol: Apctm1Hsa
Name: APC, WNT signaling pathway regulator; targeted mutation 1, Hitoshi Sasai
MGI ID: MGI:2387050
Synonyms: Apcdelta474
Gene: Apc  Location: Chr18:34220924-34322552 bp, + strand  Genetic Position: Chr18, 18.53 cM
Germline Transmission:  Earliest citation of germline transmission: J:61978
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Duplication, Insertion
  Apctm1Hsa involves 1 genes/genome features (Apc) View all
Mutation detailsThe gene was disrupted at exon 9 by insertion of a neo cassette and exons 10, 7, 8, and 9. The insertion and duplication results in a frameshift and premature translation termination. The mutant allele was confirmed by RT-PCR analysis. (J:61978)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Apc Mutation:  58 strains or lines available
Original:  J:61978 Sasai H, et al., Suppression of polypogenesis in a new mouse strain with a truncated Apc(Delta474) by a novel COX-2 inhibitor, JTE-522. Carcinogenesis. 2000 May;21(5):953-8
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory