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Oprd1tm1Kff
Targeted Allele Detail
Nomenclature
Symbol: Oprd1tm1Kff
Name: opioid receptor, delta 1; targeted mutation 1, Brigitte L Kieffer
MGI ID: MGI:2387013
Synonyms: DOR-, Oprd1-
Gene: Oprd1  Location: Chr4:132110726-132144486 bp, - strand  Genetic Position: Chr4, 64.78 cM, cytoband D1-D3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:62551
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 1, which encodes the translational start codon, was replaced by a neomycin selection cassette inserted by homologous recombination. A radiolabeled binding assay demonstrated complete functional ablation in homozygous mutant mice. (J:62551)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Oprd1 Mutation:  13 strains or lines available
References
Original:  J:62551 Filliol D, et al., Mice deficient for delta- and mu-opioid receptors exhibit opposing alterations of emotional responses. Nat Genet. 2000 Jun;25(2):195-200
All:  21 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory