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Targeted Allele Detail
Symbol: Kcnq2tm1Hsa
Name: potassium voltage-gated channel, subfamily Q, member 2; targeted mutation 1, Hitoshi Sasai
MGI ID: MGI:2386963
Synonyms: KCNQ2 -
Gene: Kcnq2  Location: Chr2:181075579-181135300 bp, - strand  Genetic Position: Chr2, 103.57 cM, cytoband H3-4
Germline Transmission:  Earliest citation of germline transmission: J:62797
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 3 through 5 were replaced by a neomycin selection cassette. The deleted region encompassed 429 bp encoding the second transmembrane domain and a portion of the pore region. While normal transcript was undetected by semi-quantitative RT-PCR analysis, low levels of an aberrant transcript in which exon 2 spliced to exon 6 were observed in homozygous mutant embryos. (J:62797)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 6 assay results
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kcnq2 Mutation:  30 strains or lines available
Original:  J:62797 Watanabe H, et al., Disruption of the epilepsy KCNQ2 gene results in neural hyperexcitability. J Neurochem. 2000 Jul;75(1):28-33
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory