Rr320^tm1Mkg
Targeted Allele Detail

Summary

• Symbol: Rr320^tm1Mkg
• Name: regulatory region 320; targeted mutation 1, Mark Groudine
• MGI ID: MGI:2386945
• Synonyms: delta145, Hbb-ar^tm1Mkg
• Gene: Rr320 Location: Chr7:103501973-103526752 bp, + strand Genetic Position: Chr7, Syntenic
• Alliance: Rr320^tm1Mkg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:60714
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Modified regulatory region, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The 5' DNase hypersensitive site 1 (HS1) of the gene was replaced with a loxP site flanked neomycin resistance gene cassette and HS 4-6 were replaced with a loxP site flanked hygromycin resistance gene cassette and a partial neo cassette via homologous recombination. (J:60714)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr320 Mutation: 0 strains or lines available

References

• Original: J:60714 Bender MA, et al., Beta-globin gene switching and DNase I sensitivity of the endogenous beta-globin locus in mice do not require the locus control region. Mol Cell. 2000 Feb;5(2):387-93
• All: 1 reference(s)