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Chek2tm1Mak
Targeted Allele Detail
Nomenclature
Symbol: Chek2tm1Mak
Name: checkpoint kinase 2; targeted mutation 1, Tak Mak
MGI ID: MGI:2386905
Synonyms: Chk2-
Gene: Chek2  Location: Chr5:110839979-110874145 bp, + strand  Genetic Position: Chr5, 53.73 cM, cytoband F
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:60946
Parent Cell Line:  E14K (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 8 through 11 were replaced with a neomycin selection cassette inserted via homologous recombination. Protein was undetected in homozygous mutant mice via Western blot analysis of various tissues. (J:60946, J:78491)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Chek2 Mutation:  26 strains or lines available
References
Original:  J:60946 Hirao A, et al., DNA damage-induced activation of p53 by the checkpoint kinase Chk2 [see comments]. Science. 2000 Mar 10;287(5459):1824-7
All:  16 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/14/2017
MGI 6.08
The Jackson Laboratory