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Hic1tm1Sbb
Targeted Allele Detail
Summary
Symbol: Hic1tm1Sbb
Name: hypermethylated in cancer 1; targeted mutation 1, Stephen B Baylin
MGI ID: MGI:2386879
Synonyms: Hic1-
Gene: Hic1  Location: Chr11:75055391-75060345 bp, - strand  Genetic Position: Chr11, 45.76 cM
Alliance: Hic1tm1Sbb page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:60589
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe entire gene coding region was deleted and replaced with a lacZ-PGK-neo cassette via homologous recombination. Northern blot analysis of whole embryo total RNA showed an absence of gene expression in homozygous mutants. (J:60589)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 12 anatomical structures
Tumor Data
List all tumor models in MMHCdb carrying Hic1tm1Sbb
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hic1 Mutation:  19 strains or lines available
References
Original:  J:60589 Carter MG, et al., Mice deficient in the candidate tumor suppressor gene Hic1 exhibit developmental defects of structures affected in the Miller-Dieker syndrome. Hum Mol Genet. 2000 Feb 12;9(3):413-9
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/15/2022
MGI 6.22
The Jackson Laboratory