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Rgs9tm1Citb
Targeted Allele Detail
Nomenclature
Symbol: Rgs9tm1Citb
Name: regulator of G-protein signaling 9; targeted mutation 1, California Institute of Technology - Biology
MGI ID: MGI:2386798
Synonyms: RGS9-, RGS9-2 KO
Gene: Rgs9  Location: Chr11:109225355-109298129 bp, - strand  Genetic Position: Chr11, 71.86 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:60188
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 5.5 kb region containing exons 2-4 (encoding amino acids 19-105) was replaced with a neomycin resistance cassette via homologous recombination. Homozygous mutant animals lacked protein product as determined by Western blot analysis of retinal proteins. Mutant retinas failed to express the long form of G protein, beta 5 (GNB5-L), although normal amounts of its mRNA were still present; however, a normal protein level of the short form GNB5-S was detected in the retina and striatum of mutant mice. (J:60188, J:83620)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Rgs9 Mutation:  23 strains or lines available
References
Original:  J:60188 Chen CK, et al., Slowed recovery of rod photoresponse in mice lacking the GTPase accelerating protein RGS9-1. Nature. 2000 Feb 3;403(6769):557-60
All:  16 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/26/2020
MGI 6.15
The Jackson Laboratory