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Targeted Allele Detail
Symbol: Slc9a3r1tm1Ssl
Name: solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1; targeted mutation 1, Shirish Shenolikar
MGI ID: MGI:2386785
Synonyms: Nherf1-, NHERF-1(-), NHERF1-
Gene: Slc9a3r1  Location: Chr11:115163341-115181178 bp, + strand  Genetic Position: Chr11, 80.65 cM, cytoband E2
Germline Transmission:  Earliest citation of germline transmission: J:78606
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 1 was replaced by a neomycin selection cassette inserted by homologous recombination. Protein was undetected in homozygous mutant mice by Western blot analysis of kidney extracts and immunostaining of proximal renal tubules. (J:78606)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Slc9a3r1 Mutation:  15 strains or lines available
Original:  J:78606 Shenolikar S, et al., Targeted disruption of the mouse NHERF-1 gene promotes internalization of proximal tubule sodium-phosphate cotransporter type IIa and renal phosphate wasting. Proc Natl Acad Sci U S A. 2002 Aug 20;99(17):11470-5
All:  25 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory