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Targeted Allele Detail
Symbol: Gata4tm1.1Sho
Name: GATA binding protein 4; targeted mutation 1.1, Stuart Orkin
MGI ID: MGI:2386766
Gene: Gata4  Location: Chr14:63198922-63271692 bp, - strand  Genetic Position: Chr14, 33.24 cM
Germline Transmission:  Earliest citation of germline transmission: J:77392
Parent Cell Line:  TL1/TL-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted
Mutation:    Nucleotide substitutions
Mutation detailsIn vivo expression of cre recombinase resulted in the excision of an intronic floxed neo cassette from Gata4tm1Sho. The valine to glycine substitution mutation introduced into codon 217 by site directed mutagenesis was left intact. (J:77392)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Gata4 Mutation:  23 strains or lines available
Original:  J:77392 Crispino JD, et al., Proper coronary vascular development and heart morphogenesis depend on interaction of GATA-4 with FOG cofactors. Genes Dev. 2001 Apr 1;15(7):839-44
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory