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Targeted Allele Detail
Symbol: Esr2tm1Mma
Name: estrogen receptor 2 (beta); targeted mutation 1, Manuel Mark
MGI ID: MGI:2386761
Synonyms: BERKO, ERbeta-
Gene: Esr2  Location: Chr12:76120419-76177259 bp, - strand  Genetic Position: Chr12, 33.52 cM, cytoband D1-D3
Germline Transmission:  Earliest citation of germline transmission: J:64426
Parent Cell Line:  H1 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsThe gene was disrupted by insertion of a neomycin resistance cassette into exon 3 encoding the first zinc finger domain via homologous recombination. RT-PCR analysis of ovary mRNA from mutant animals detected 3 faint RNA species all lacking exon 3. Immunohistochemical analysis of ovary sections from homozygous mutant animals did not detect protein product. (J:64426)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Esr2 Mutation:  24 strains or lines available
Original:  J:64426 Dupont S, et al., Effect of single and compound knockouts of estrogen receptors alpha (ERalpha) and beta (ERbeta) on mouse reproductive phenotypes. Development. 2000 Oct;127(19):4277-91
All:  34 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory