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Targeted Allele Detail
Symbol: Mafktm1Jeng
Name: v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian); targeted mutation 1, James Douglas Engel
MGI ID: MGI:2386716
Synonyms: mafK-
Gene: Mafk  Location: Chr5:139791536-139802653 bp, + strand  Genetic Position: Chr5, 78.81 cM
Germline Transmission:  Earliest citation of germline transmission: J:78982
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA portion of exon 2 and all of exon 3 were replaced by a cassette inserted downstream of the translational start codon and containing lacZ and floxed neo genes. RNAse protection assays were utilized to confirm the absence of transcript in homozygous mutant mice. Expression of beta-galactosidase was driven by the endogenous promoter. (J:78982)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 39 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mafk Mutation:  5 strains or lines available
Original:  J:78982 Shavit JA, et al., Impaired megakaryopoiesis and behavioral defects in mafG-null mutant mice. Genes Dev. 1998 Jul 15;12(14):2164-74
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
The Jackson Laboratory