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Targeted Allele Detail
Symbol: Il1rl1tm1Anjm
Name: interleukin 1 receptor-like 1; targeted mutation 1, Andrew NJ McKenzie
MGI ID: MGI:2386675
Synonyms: ST2-, T1/ST2-
Gene: Il1rl1  Location: Chr1:40429570-40465415 bp, + strand  Genetic Position: Chr1, 19.19 cM
Germline Transmission:  Earliest citation of germline transmission: J:61108
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsPortions of exons 4 and 5 were replaced by a neomycin selection cassette inserted at the endogenous locus via homologous recombination. The deleted region encoded a portion of the extracellular domain which is common to both membrane bound and soluble forms of the protein. RT-PCR analysis of activated lymphocytes showed an absence of normal transcript in homozygous mutant mice. Cell surface expression of the encoded protien was undetected by flow cytometric analysis of cultured mast cells. (J:61108)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Il1rl1 Mutation:  18 strains or lines available
Original:  J:61108 Townsend MJ, et al., T1/ST2-deficient mice demonstrate the importance of T1/ST2 in developing primary T helper cell type 2 responses. J Exp Med. 2000 Mar 20;191(6):1069-76
All:  134 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
The Jackson Laboratory