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Npr1tm1Kuhn
Targeted Allele Detail
Nomenclature
Symbol: Npr1tm1Kuhn
Name: natriuretic peptide receptor 1; targeted mutation 1, Michaela Kuhn
MGI ID: MGI:2386604
Synonyms: floxed GC-A, GC-A3lox
Gene: Npr1  Location: Chr3:90450591-90465866 bp, - strand  Genetic Position: Chr3, 39.23 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:76460
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsExon 1, which contains the translational start codon, was flanked by an upstream floxed neo cassette and a downstream single loxP site. Quantitative RT-PCR of RNA obtained from aorta and pulmonary artery tissue showed normal levels of transcript in homozygous mutant mice. (J:76460)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Npr1 Mutation:  26 strains or lines available
References
Original:  J:76460 Holtwick R, et al., Smooth muscle-selective deletion of guanylyl cyclase-A prevents the acute but not chronic effects of ANP on blood pressure. Proc Natl Acad Sci U S A. 2002 May 14;99(10):7142-7
All:  16 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory