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Targeted Allele Detail
Symbol: Vegfatm4Pec
Name: vascular endothelial growth factor A; targeted mutation 4, Peter Carmeliet
MGI ID: MGI:2386595
Synonyms: VEGF188
Gene: Vegfa  Location: Chr17:46016993-46032369 bp, - strand  Genetic Position: Chr17, 22.79 cM
Germline Transmission:  Earliest citation of germline transmission: J:75507
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted
Mutations:    Insertion, Intragenic deletion
Mutation detailsGenomic sequence containing exons 4 through 8 was replaced with corresponding cDNA. The resultant allele lacks splice sites and thereby produces a single isoform with high receptor binding properties. The exclusive presence of this isoform was verified by quatitative RT-PCR. (J:75507)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Vegfa Mutation:  7 strains or lines available
Original:  J:75507 Stalmans I, et al., Arteriolar and venular patterning in retinas of mice selectively expressing VEGF isoforms. J Clin Invest. 2002 Feb;109(3):327-36
All:  5 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.21
The Jackson Laboratory