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Vegfatm4Pec
Targeted Allele Detail
Nomenclature
Symbol: Vegfatm4Pec
Name: vascular endothelial growth factor A; targeted mutation 4, Peter Carmeliet
MGI ID: MGI:2386595
Synonyms: VEGF188
Gene: Vegfa  Location: Chr17:46016993-46032369 bp, - strand  Genetic Position: Chr17, 22.79 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:75507
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsGenomic sequence containing exons 4 through 8 was replaced with corresponding cDNA. The resultant allele lacks splice sites and thereby produces a single isoform with high receptor binding properties. The exclusive presence of this isoform was verified by quatitative RT-PCR. (J:75507)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 15 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Vegfa Mutation:  20 strains or lines available
References
Original:  J:75507 Stalmans I, et al., Arteriolar and venular patterning in retinas of mice selectively expressing VEGF isoforms. J Clin Invest. 2002 Feb;109(3):327-36
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory