Vegfa^tm4Pec
Targeted Allele Detail

Summary

• Symbol: Vegfa^tm4Pec
• Name: vascular endothelial growth factor A; targeted mutation 4, Peter Carmeliet
• MGI ID: MGI:2386595
• Synonyms: VEGF¹⁸⁸
• Gene: Vegfa Location: Chr17:46327919-46343295 bp, - strand Genetic Position: Chr17, 22.79 cM
• Alliance: Vegfa^tm4Pec page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75507
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intragenic deletion
• Mutation details: Genomic sequence containing exons 4 through 8 was replaced with corresponding cDNA. The resultant allele lacks splice sites and thereby produces a single isoform with high receptor binding properties. The exclusive presence of this isoform was verified by quatitative RT-PCR. (J:75507)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	14 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Vegfa Mutation: 37 strains or lines available

References

• Original: J:75507 Stalmans I, et al., Arteriolar and venular patterning in retinas of mice selectively expressing VEGF isoforms. J Clin Invest. 2002 Feb;109(3):327-36
• All: 10 reference(s)