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Polbtm1Koy
Targeted Allele Detail
Nomenclature
Symbol: Polbtm1Koy
Name: polymerase (DNA directed), beta; targeted mutation 1, Hideki Koyama
MGI ID: MGI:2386539
Synonyms: PolBeta-
Gene: Polb  Location: Chr8:22628126-22653435 bp, - strand  Genetic Position: Chr8, 11.42 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:61143
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 1 and 2 were replaced with a neomycin selection cassette by homologous recombination. Neither transcript nor protein was detected by Northern blot and Western blot analyses of homozygous mutant embyros. (J:61143)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 3 assay results
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Polb Mutation:  3 strains or lines available
References
Original:  J:61143 Sugo N, et al., Neonatal lethality with abnormal neurogenesis in mice deficient in DNA polymerase beta. EMBO J. 2000 Mar 15;19(6):1397-404
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/30/2020
MGI 6.15
The Jackson Laboratory