Polb^tm1Koy
Targeted Allele Detail

Summary

• Symbol: Polb^tm1Koy
• Name: polymerase (DNA directed), beta; targeted mutation 1, Hideki Koyama
• MGI ID: MGI:2386539
• Synonyms: PolBeta^-
• Gene: Polb Location: Chr8:23118142-23143451 bp, - strand Genetic Position: Chr8, 11.42 cM
• Alliance: Polb^tm1Koy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:61143
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 and 2 were replaced with a neomycin selection cassette by homologous recombination. Neither transcript nor protein was detected by Northern blot and Western blot analyses of homozygous mutant embyros. (J:61143)

Expression

In Mice Carrying this Mutation:	3 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Polb Mutation: 28 strains or lines available

References

• Original: J:61143 Sugo N, et al., Neonatal lethality with abnormal neurogenesis in mice deficient in DNA polymerase beta. EMBO J. 2000 Mar 15;19(6):1397-404
• All: 5 reference(s)