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Rfx5tm1Ifo
Targeted Allele Detail
Nomenclature
Symbol: Rfx5tm1Ifo
Name: regulatory factor X, 5 (influences HLA class II expression); targeted mutation 1, Irmgard Foerster
MGI ID: MGI:2386499
Synonyms: Rfx5flox
Gene: Rfx5  Location: Chr3:94954075-94961561 bp, + strand  Genetic Position: Chr3, 40.74 cM, cytoband F2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:67941
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsExons 4 through 7, encoding the DNA binding domain, were flanked by an upstream floxed neo cassette and a downstream single loxP site. (J:67941)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Rfx5 Mutation:  22 strains or lines available
References
Original:  J:67941 Clausen BE, et al., Residual MHC class II expression on mature dendritic cells and activated B cells in RFX5-deficient mice. Immunity. 1998 Feb;8(2):143-55
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/31/2020
MGI 6.15
The Jackson Laboratory