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Mst1rtm1Sew
Targeted Allele Detail
Nomenclature
Symbol: Mst1rtm1Sew
Name: macrophage stimulating 1 receptor (c-met-related tyrosine kinase); targeted mutation 1, Susan E Waltz
MGI ID: MGI:2386413
Gene: Mst1r  Location: Chr9:107906873-107920383 bp, + strand  Genetic Position: Chr9, 59.07 cM, cytoband F1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:75503
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsExons 13 through 18 were left flanked by single loxP sites after a floxed hprt gene was excised by the in vitro expression of cre recombinase. Exons 13 through 18 encode the tyrosine kinase domain which is essential for catalytic activity. (J:75503)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mst1r Mutation:  32 strains or lines available
References
Original:  J:75503 Waltz SE, et al., Ron-mediated cytoplasmic signaling is dispensable for viability but is required to limit inflammatory responses. J Clin Invest. 2001 Aug;108(4):567-76
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory