Mst1r^tm1Sew
Targeted Allele Detail

Summary

• Symbol: Mst1r^tm1Sew
• Name: macrophage stimulating 1 receptor (c-met-related tyrosine kinase); targeted mutation 1, Susan E Waltz
• MGI ID: MGI:2386413
• Gene: Mst1r Location: Chr9:107784072-107797582 bp, + strand Genetic Position: Chr9, 59.07 cM, cytoband F1
• Alliance: Mst1r^tm1Sew page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75503
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 13 through 18 were left flanked by single loxP sites after a floxed hprt gene was excised by the in vitro expression of cre recombinase. Exons 13 through 18 encode the tyrosine kinase domain which is essential for catalytic activity. (J:75503)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mst1r Mutation: 59 strains or lines available

References

• Original: J:75503 Waltz SE, et al., Ron-mediated cytoplasmic signaling is dispensable for viability but is required to limit inflammatory responses. J Clin Invest. 2001 Aug;108(4):567-76
• All: 5 reference(s)