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Targeted Allele Detail
Symbol: Smad4tm2Cxd
Name: SMAD family member 4; targeted mutation 2, Chu-Xia Deng
MGI ID: MGI:2386390
Synonyms: Smad4neo-Co
Gene: Smad4  Location: Chr18:73639009-73703780 bp, - strand  Genetic Position: Chr18, 49.51 cM
Germline Transmission:  Earliest citation of germline transmission: J:75140
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsExon 8 was flanked by a single loxP site in intron 7 and a floxed neo cassette in intron 8. The presence of the neo cassette was found to interfere with normal splicing, resulting in lethality of homozygous embryos. Mice carrying this allele were bred with mice expressing cre recombinase via the EIIa promoter to excise either the neo cassette or the neo cassette and exon 8 together. (J:75140)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Smad4 Mutation:  13 strains or lines available
Original:  J:75140 Yang X, et al., Generation of Smad4/Dpc4 conditional knockout mice. Genesis. 2002 Feb;32(2):80-1
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory