About   Help   FAQ
Prox1tm1Gco
Targeted Allele Detail
Nomenclature
Symbol: Prox1tm1Gco
Name: prospero homeobox 1; targeted mutation 1, Guillermo Oliver
MGI ID: MGI:2386336
Synonyms: Prox1-, ProxLacZ
Gene: Prox1  Location: Chr1:190118035-190170714 bp, - strand  Genetic Position: Chr1, 95.85 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:53431
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation details
Phenotypes
Loading...
View phenotypes for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Mice Carrying this Mutation: 37 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Prox1 Mutation:  7 strains or lines available
Notes

In J:53431, the original chimeric mice were crossed to four different genetic backgrounds. In three (unspecified) backgrounds mortality was 100% penetrant, whereas crosses to the NMRI background produced some surviving heterozygotes, which were used to generate homozygous embryos.

References
Original:  J:53431 Wigle JT, et al., Prox1 function is crucial for mouse lens-fibre elongation. Nat Genet. 1999 Mar;21(3):318-22
All:  16 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/26/2014
MGI 5.19
The Jackson Laboratory