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Slc18a2tm1Mca
Targeted Allele Detail
Nomenclature
Symbol: Slc18a2tm1Mca
Name: solute carrier family 18 (vesicular monoamine), member 2; targeted mutation 1, Marc G Caron
MGI ID: MGI:2386330
Synonyms: VMAT2-
Gene: Slc18a2  Location: Chr19:59260878-59296012 bp, + strand  Genetic Position: Chr19, 54.64 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:45184
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe sequences encoding transmembrane domains 3 and 4 were deleted and replaced with a PGK-neo cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by RT-PCR analysis and Western blot of whole brain RNA and synatpic vesicles from newborn animals. Binding assays using proteins prepared from synaptic vesicles showed no binding activity in the homozygous mutants. (J:45184)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc18a2 Mutation:  8 strains or lines available
References
Original:  J:45184 Wang YM, et al., Knockout of the vesicular monoamine transporter 2 gene results in neonatal death and supersensitivity to cocaine and amphetamine. Neuron. 1997 Dec;19(6):1285-96
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory