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Targeted Allele Detail
Symbol: Kat2btm1Nkt
Name: K(lysine) acetyltransferase 2B; targeted mutation 1, Yoshihiro Nakatani
MGI ID: MGI:2386307
Synonyms: PCAF-
Gene: Kat2b  Location: Chr17:53566861-53672720 bp, + strand  Genetic Position: Chr17, 27.86 cM
Germline Transmission:  Earliest citation of germline transmission: J:65264
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe exon encoding amino acids 1 through 88 was replaced with a neomycin selection cassette. The absence of protein in homozygous mutant mice was verifed by Western blot analysis of brain, lung, and liver tissue. (J:65264)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Kat2b Mutation:  103 strains or lines available
Original:  J:65264 Yamauchi T, et al., Distinct but overlapping roles of histone acetylase PCAF and of the closely related PCAF-B/GCN5 in mouse embryogenesis. Proc Natl Acad Sci U S A. 2000 Oct 10;97(21):11303-6
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory