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Targeted Allele Detail
Symbol: Adcyap1r1tm1Aba
Name: adenylate cyclase activating polypeptide 1 receptor 1; targeted mutation 1, Akemichi Baba
MGI ID: MGI:2386283
Synonyms: exon 2-
Gene: Adcyap1r1  Location: Chr6:55451978-55501451 bp, + strand  Genetic Position: Chr6, 27.38 cM, cytoband B3
Germline Transmission:  Earliest citation of germline transmission: J:65199
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsThe insertion of a neomycin selection cassette disrupted exon 2, which encodes the 5' untranslated region, the start codon, and the majority of the signal peptide. Northern blot and RT-PCR analyses identified an aberrant transcript in which exon 1 had spliced to exon 3. In vitro studies of the protein generated from a start codon in exon 3 of this transcript showed improper localization and post-translational processing. Specifically, cell surface expression of the mutant protein was reduced and it was largely unglycosylated. (J:65199)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Adcyap1r1 Mutation:  17 strains or lines available
Original:  J:65199 Hashimoto H, et al., Mice with markedly reduced PACAP (PAC(1)) receptor expression by targeted deletion of the signal peptide. J Neurochem. 2000 Nov;75(5):1810-7
All:  3 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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