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Chuktm1Ver
Targeted Allele Detail
Summary
Symbol: Chuktm1Ver
Name: conserved helix-loop-helix ubiquitous kinase; targeted mutation 1, Inder M Verma
MGI ID: MGI:2386272
Synonyms: IKK1-
Gene: Chuk  Location: Chr19:44061774-44095919 bp, - strand  Genetic Position: Chr19, 36.71 cM
Alliance: Chuktm1Ver page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:55415
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 3 kb region containing the promoter, exon 1, and part of intron 1 was replaced with a PGK-neo cassette via homologous recombination. The null allele was confirmed by Western blot analysis performed on primary embryonic fibroblasts cultured from homozygous mutant embryos. No protein expression was detected. (J:55415)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 28 assay results
In Structures Affected by this Mutation: 21 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Chuk Mutation:  48 strains or lines available
References
Original:  J:55415 Li Q, et al., IKK1-deficient mice exhibit abnormal development of skin and skeleton. Genes Dev. 1999 May 15;13(10):1322-8
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory