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Tyrobptm1.1Viv
Targeted Allele Detail
Nomenclature
Symbol: Tyrobptm1.1Viv
Name: TYRO protein tyrosine kinase binding protein; targeted mutation 1.1, Eric Vivier
MGI ID: MGI:2386271
Synonyms: DAP12-, DAP12KI, Kdelta75, KDeltaY75
Gene: Tyrobp  Location: Chr7:30413788-30417577 bp, + strand  Genetic Position: Chr7, 17.45 cM, cytoband B
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:64764
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe floxed neo cassette was excised from Tyrobptm1Viv via ubiquitous in vivo expression of cre recombinase. RT-PCR analysis showed that the sequence inserted to replace a region encoding a portion of the immunoreceptor tyrosine-based activation motif (ITAM) was left intact along with a single upstream loxP site. (J:64764)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tyrobp Mutation:  3 strains or lines available
References
Original:  J:64764 Tomasello E, et al., Combined natural killer cell and dendritic cell functional deficiency in KARAP/DAP12 loss-of-function mutant mice. Immunity. 2000 Sep;13(3):355-64
All:  19 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/20/2015
MGI 5.21
The Jackson Laboratory