Tyrobp^tm1.1Viv
Targeted Allele Detail

Summary

• Symbol: Tyrobp^tm1.1Viv
• Name: TYRO protein tyrosine kinase binding protein; targeted mutation 1.1, Eric Vivier
• MGI ID: MGI:2386271
• Synonyms: DAP12^-, DAP12^KI, Kdelta75, KDeltaY75
• Gene: Tyrobp Location: Chr7:30113207-30117007 bp, + strand Genetic Position: Chr7, 17.45 cM, cytoband B
• Alliance: Tyrobp^tm1.1Viv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:64764
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intragenic deletion
• Mutation details: The floxed neo cassette was excised from Tyrobp^tm1Viv via ubiquitous in vivo expression of cre recombinase. RT-PCR analysis showed that the sequence inserted to replace a region encoding a portion of the immunoreceptor tyrosine-based activation motif (ITAM) was left intact along with a single upstream loxP site. (J:64764)

Disease models

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tyrobp Mutation: 10 strains or lines available

References

• Original: J:64764 Tomasello E, et al., Combined natural killer cell and dendritic cell functional deficiency in KARAP/DAP12 loss-of-function mutant mice. Immunity. 2000 Sep;13(3):355-64
• All: 24 reference(s)