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C3tm1Pkna
Targeted Allele Detail
Nomenclature
Symbol: C3tm1Pkna
Name: complement component 3; targeted mutation 1, Marcela Pekna
MGI ID: MGI:2386266
Synonyms: C3-, C3tm1Pkny
Gene: C3  Location: Chr17:57203970-57228136 bp, - strand  Genetic Position: Chr17, 29.72 cM, cytoband E1-E3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:45857
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details3.5 kb of the gene, a region including exon 24, was replaced with a neomycin resistance cassette via homologous recombination. Western blot analysis showed an absence of C3 beta-chain protein in the serum of homozygous mutant animals. Similarly, ELISA assay did not detect C3 protein in serum from homozygous animals. (J:45857)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any C3 Mutation:  10 strains or lines available
References
Original:  J:45857 Pekna M, et al., Targeted disruption of the murine gene coding for the third complement component (C3). Scand J Immunol. 1998 Jan;47(1):25-9
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory