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Targeted Allele Detail
Symbol: Sdc4tm1Goe
Name: syndecan 4; targeted mutation 1, Paul F Goetinck
MGI ID: MGI:2386199
Synonyms: S4-, Sdc4lacZ
Gene: Sdc4  Location: Chr2:164424247-164443887 bp, - strand  Genetic Position: Chr2, 85.16 cM
Germline Transmission:  Earliest citation of germline transmission: J:67007
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 1 through 3 were replaced by a cassette containing an IRES-beta-galactosidase and neo fusion gene. RT-PCR and flow cytometric analyses of skin fibroblasts confirmed the absence of normal transcript and the lack of protein surface expression in homozygous mutant mice. X-gal staining was not reported. (J:67007)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 12 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sdc4 Mutation:  22 strains or lines available
Original:  J:67007 Echtermeyer F, et al., Delayed wound repair and impaired angiogenesis in mice lacking syndecan-4. J Clin Invest. 2001 Jan;107(2):R9-R14
All:  20 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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