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Sdc4tm1Goe
Targeted Allele Detail
Nomenclature
Symbol: Sdc4tm1Goe
Name: syndecan 4; targeted mutation 1, Paul F Goetinck
MGI ID: MGI:2386199
Synonyms: S4-, Sdc4lacZ
Gene: Sdc4  Location: Chr2:164424247-164443887 bp, - strand  Genetic Position: Chr2, 85.16 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:67007
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 1 through 3 were replaced by a cassette containing an IRES-beta-galactosidase and neo fusion gene. RT-PCR and flow cytometric analyses of skin fibroblasts confirmed the absence of normal transcript and the lack of protein surface expression in homozygous mutant mice. X-gal staining was not reported. (J:67007)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 12 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sdc4 Mutation:  21 strains or lines available
References
Original:  J:67007 Echtermeyer F, et al., Delayed wound repair and impaired angiogenesis in mice lacking syndecan-4. J Clin Invest. 2001 Jan;107(2):R9-R14
All:  19 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory