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Pdcd1tm1Hon
Targeted Allele Detail
Nomenclature
Symbol: Pdcd1tm1Hon
Name: programmed cell death 1; targeted mutation 1, Tasuku Honjo
MGI ID: MGI:2386184
Synonyms: PD-1-
Gene: Pdcd1  Location: Chr1:94038305-94052553 bp, - strand  Genetic Position: Chr1, 47.47 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:50688
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 6 strains available      Cell Lines: 0 lines available
Carrying any Pdcd1 Mutation:  10 strains or lines available
Notes

Phenotypic Similarity to Human Syndrome: Autoimmune Cystitis J:207275

References
Original:  J:50688 Nishimura H, et al., Immunological studies on PD-1 deficient mice: implication of PD-1 as a negative regulator for B cell responses. Int Immunol. 1998 Oct;10(10):1563-72
All:  83 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory