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Aff1tm1Cim
Targeted Allele Detail
Nomenclature
Symbol: Aff1tm1Cim
Name: AF4/FMR2 family, member 1; targeted mutation 1, Centre d'Immunologie de Marseille Luminy
MGI ID: MGI:2386161
Synonyms: mAF4-
Gene: Aff1  Location: Chr5:103692374-103855322 bp, + strand  Genetic Position: Chr5, 50.45 cM, cytoband E
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:63253
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe gene was disrupted by replacement of part of exon 11 with a PGK-neo cassette via homologous recombination. Northern blot and RT-PCR analysis confirmed the absence of gene expression in homozygous mutant animals. (J:63253)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Aff1 Mutation:  289 strains or lines available
References
Original:  J:63253 Isnard P, et al., Altered lymphoid development in mice deficient for the mAF4 proto-oncogene. Blood. 2000 Jul 15;96(2):705-10
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/08/2017
MGI 6.10
The Jackson Laboratory