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Hrastm1Mok
Targeted Allele Detail
Nomenclature
Symbol: Hrastm1Mok
Name: Harvey rat sarcoma virus oncogene; targeted mutation 1, Moyota Katsuki
MGI ID: MGI:2386128
Synonyms: H-ras (-)
Gene: Hras  Location: Chr7:141189105-141194005 bp, - strand  Genetic Position: Chr7, 86.48 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:62962
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe exons encoding the first 160 amino acids of the gene were replaced with a neomycin resistance cassette via homologous recombination. Skin lysates from homozygous mutant animals contained no detectable protein product as determined by Western blot analysis. (J:62962)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 15 strains available      Cell Lines: 0 lines available
Carrying any Hras Mutation:  20 strains or lines available
References
Original:  J:62962 Ise K, et al., Targeted deletion of the H-ras gene decreases tumor formation in mouse skin carcinogenesis. Oncogene. 2000 Jun 15;19(26):2951-6
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/18/2017
MGI 6.08
The Jackson Laboratory