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Gjc1tm1Kwi
Targeted Allele Detail
Nomenclature
Symbol: Gjc1tm1Kwi
Name: gap junction protein, gamma 1; targeted mutation 1, Klaus Willecke
MGI ID: MGI:2386124
Synonyms: Cx45-, Cx45lacZ
Gene: Gjc1  Location: Chr11:102799579-102819700 bp, - strand  Genetic Position: Chr11, 66.48 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:64428
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprtb-m3
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation details663 bp of the gene just downstream of the start codon was replaced with a promoterless lacZ-neo cassette via homologous recombination. (J:64428)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 3 assay results
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gjc1 Mutation:  17 strains or lines available
References
Original:  J:64428 Kruger O, et al., Defective vascular development in connexin 45-deficient mice. Development. 2000 Oct;127(19):4179-93
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/17/2019
MGI 6.14
The Jackson Laboratory