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Pigatm1Tak
Targeted Allele Detail
Nomenclature
Symbol: Pigatm1Tak
Name: phosphatidylinositol glycan anchor biosynthesis, class A; targeted mutation 1, Junji Takeda
MGI ID: MGI:2386120
Synonyms: Pig-aflox
Gene: Piga  Location: ChrX:164419793-164433916 bp, + strand  Genetic Position: ChrX, 76.49 cM, cytoband F3-F4
Epidermal morphology of wild type and Pigatm1Tak/Y Tg(KRT5-cre)1Tak mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:41746
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsExon 6 was left flanked by loxP sites after the in vitro expression of cre recombinase. The potential for cre-mediated recombination was demonstrated in ES cells. (J:41746)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Piga Mutation:  3 strains or lines available
References
Original:  J:41746 Tarutani M, et al., Tissue-specific knockout of the mouse Pig-a gene reveals important roles for GPI-anchored proteins in skin development. Proc Natl Acad Sci U S A. 1997 Jul 8;94(14):7400-5
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/20/2015
MGI 5.21
The Jackson Laboratory