Piga^tm1Tak
Targeted Allele Detail

Summary

• Symbol: Piga^tm1Tak
• Name: phosphatidylinositol glycan anchor biosynthesis, class A; targeted mutation 1, Junji Takeda
• MGI ID: MGI:2386120
• Synonyms: Pig-a^flox
• Gene: Piga Location: ChrX:163202814-163216912 bp, + strand Genetic Position: ChrX, 76.49 cM, cytoband F3-F4
• Alliance: Piga^tm1Tak page

Epidermal morphology of wild type and Piga^tm1Tak/Y Tg(KRT5-cre)1Tak mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:41746
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 6 was left flanked by loxP sites after the in vitro expression of cre recombinase. The potential for cre-mediated recombination was demonstrated in ES cells. (J:41746)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Piga Mutation: 3 strains or lines available

References

• Original: J:41746 Tarutani M, et al., Tissue-specific knockout of the mouse Pig-a gene reveals important roles for GPI-anchored proteins in skin development. Proc Natl Acad Sci U S A. 1997 Jul 8;94(14):7400-5
• All: 18 reference(s)