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Nr1i2tm1Rev
Targeted Allele Detail
Nomenclature
Symbol: Nr1i2tm1Rev
Name: nuclear receptor subfamily 1, group I, member 2; targeted mutation 1, Ronald M Evans
MGI ID: MGI:2386087
Synonyms: PXR-, PXR-null
Gene: Nr1i2  Location: Chr16:38248323-38294824 bp, - strand  Genetic Position: Chr16, 26.64 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:63639
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 2 and 3 encoding amino acids 63-170 of the DNA-binding domain were replaced with a PGK-neo cassette via homologous recombination. Northern blot analysis confirmed the absence of gene expression in the liver and small intestine of homozygous mutant animals. (J:63639)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nr1i2 Mutation:  19 strains or lines available
References
Original:  J:63639 Xie W, et al., Humanized xenobiotic response in mice expressing nuclear receptor SXR. Nature. 2000 Jul 27;406(6794):435-9
All:  21 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/16/2017
MGI 6.09
The Jackson Laboratory