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Serpinh1tm1Kzn
Targeted Allele Detail
Summary
Symbol: Serpinh1tm1Kzn
Name: serine (or cysteine) peptidase inhibitor, clade H, member 1; targeted mutation 1, Kazuhiro Nagata
MGI ID: MGI:2385994
Synonyms: Hsp47-
Gene: Serpinh1  Location: Chr7:98994583-99002446 bp, - strand  Genetic Position: Chr7, 54.07 cM
Alliance: Serpinh1tm1Kzn page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:64899
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe gene was disrupted by replacement of exon 4 and part of exon 5 with a neomycin resistance cassette via homologous recombination. Homozygous mutant embryos were detected by Southern blot up to day E10.5. Homozygous mutant embryos lacked gene expression as demonstrated by RT-PCR and Western blot analysis. (J:64899)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Serpinh1 Mutation:  52 strains or lines available
References
Original:  J:64899 Nagai N, et al., Embryonic lethality of molecular chaperone hsp47 knockout mice is associated with defects in collagen biosynthesis. J Cell Biol. 2000 Sep 18;150(6):1499-506
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/22/2022
MGI 6.22
The Jackson Laboratory