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Targeted Allele Detail
Symbol: Nrastm1Rak
Name: neuroblastoma ras oncogene; targeted mutation 1, Raju Kucherlapati
MGI ID: MGI:2385944
Synonyms: N-ras-
Gene: Nras  Location: Chr3:103058285-103067914 bp, + strand  Genetic Position: Chr3, 45.25 cM
Germline Transmission:  Earliest citation of germline transmission: J:23318
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation details2.2 kb of sequence from the 3' portion of exon 2 were replaced with a neomycin selection cassette via homologous recombination. The deleted sequence encoded two thirds of the carboxy terminal amino acids. Protein was undetected by Western blot analysis of extracts obtained from the lungs of homozygous mutant mice. (J:23318)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 15 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nras Mutation:  23 strains or lines available
Original:  J:23318 Umanoff H, et al., The murine N-ras gene is not essential for growth and development. Proc Natl Acad Sci U S A. 1995 Feb 28;92(5):1709-13
All:  18 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory