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Rxratm1Krc
Targeted Allele Detail
Nomenclature
Symbol: Rxratm1Krc
Name: retinoid X receptor alpha; targeted mutation 1, Kenneth R Chien
MGI ID: MGI:2385918
Synonyms: RXRalphafl, RXRalphaflox, RXRalphafloxed
Gene: Rxra  Location: Chr2:27676440-27762957 bp, + strand  Genetic Position: Chr2, 19.38 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:48085
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was introduced into intron 3 and a floxed PGK-neo-tk cassette was introduced into intron 4 via homologous recombination. The PGK-neo-tk cassette was subsequently removed in correctly targeted cells by the transient expression of cre recombinase, leaving behind loxP sites flanking exon 4. (J:48085)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 10 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Rxra Mutation:  9 strains or lines available
References
Original:  J:48085 Chen J, et al., Ventricular muscle-restricted targeting of the RXRalpha gene reveals a non-cell-autonomous requirement in cardiac chamber morphogenesis. Development. 1998 May;125(10):1943-9
All:  25 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory