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Dmrt1tm1.1Zark
Targeted Allele Detail
Nomenclature
Symbol: Dmrt1tm1.1Zark
Name: doublesex and mab-3 related transcription factor 1; targeted mutation 1.1, David Zarkower
MGI ID: MGI:2385912
Synonyms: Dmrt1-
Gene: Dmrt1  Location: Chr19:25505618-25604329 bp, + strand  Genetic Position: Chr19, 20.45 cM, cytoband C2-C3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:65541
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThe floxed sequences of Dmrt1tm1Zark were deleted by mating mice carrying this allele to the cre-expressing TgN(ACTB-cre)2Mrt line. The cre-mediated recombination event removes the promoter, the major translation initiation codon, exon 1 (which contains the zinc-finger-like DM domain), the neomycin resistance gene, and part of intron 1. Homozygous mutant animals did not express protein product as demonstrated by immunohistochemical analysis of testes sections. (J:65541)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dmrt1 Mutation:  28 strains or lines available
References
Original:  J:65541 Raymond CS, et al., Dmrt1, a gene related to worm and fly sexual regulators, is required for mammalian testis differentiation. Genes Dev. 2000 Oct 15;14(20):2587-95
All:  6 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory