About   Help   FAQ
Dmrt1tm1.1Zark
Targeted Allele Detail
Nomenclature
Symbol: Dmrt1tm1.1Zark
Name: doublesex and mab-3 related transcription factor 1; targeted mutation 1.1, David Zarkower
MGI ID: MGI:2385912
Synonyms: Dmrt1-
Gene: Dmrt1  Location: Chr19:25505618-25604329 bp, + strand  Genetic Position: Chr19, 20.45 cM, cytoband C2-C3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:65541
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThe floxed sequences of Dmrt1tm1Zark were deleted by mating mice carrying this allele to the cre-expressing TgN(ACTB-cre)2Mrt line. The cre-mediated recombination event removes the promoter, the major translation initiation codon, exon 1 (which contains the zinc-finger-like DM domain), the neomycin resistance gene, and part of intron 1. Homozygous mutant animals did not express protein product as demonstrated by immunohistochemical analysis of testes sections. (J:65541)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dmrt1 Mutation:  28 strains or lines available
References
Original:  J:65541 Raymond CS, et al., Dmrt1, a gene related to worm and fly sexual regulators, is required for mammalian testis differentiation. Genes Dev. 2000 Oct 15;14(20):2587-95
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/16/2017
MGI 6.09
The Jackson Laboratory