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Targeted Allele Detail
Symbol: Cd27tm1Jbo
Name: CD27 antigen; targeted mutation 1, Jannie Borst
MGI ID: MGI:2385835
Synonyms: CD27-, Tnfrsf7-
Gene: Cd27  Location: Chr6:125232622-125237010 bp, - strand  Genetic Position: Chr6, 59.32 cM
Germline Transmission:  Earliest citation of germline transmission: J:65516
Parent Cell Line:  IB10/E14IB10 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe entire coding region of the gene was replaced with a PGK-hygro cassette via homologous recombination. Immunofluorescence flow cytometry of spleen cells from homozygous mutant animals confirmed the absence of protein expression. (J:65516)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cd27 Mutation:  12 strains or lines available
Original:  J:65516 Hendriks J, et al., CD27 is required for generation and long-term maintenance of T cell immunity. Nat Immunol. 2000 Nov;1(5):433-40
All:  39 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory