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Targeted Allele Detail
Symbol: Lhx3tm1Lmgd
Name: LIM homeobox protein 3; targeted mutation 1, Laboratory of Mammalian Genes and Development, Heiner Westphal
MGI ID: MGI:2385819
Synonyms: Lhx3-
Gene: Lhx3  Location: Chr2:26200212-26208249 bp, - strand  Genetic Position: Chr2, 18.44 cM, cytoband A2-C1
Germline Transmission:  Earliest citation of germline transmission: J:33050
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsSequences encoding the two LIM domains and a portion of the homeodomain were replaced with a neomycin selection cassette. Transcript was undetected by in situ hybridization analysis of mutant embryos. (J:33050)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 44 assay results
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lhx3 Mutation:  22 strains or lines available
Original:  J:33050 Sheng HZ, et al., Specification of pituitary cell lineages by the LIM homeobox gene Lhx3. Science. 1996 May 17;272(5264):1004-7
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory